DrySyn Evaluation: Laura Spawls, University of East Anglia

Posted on: April 7, 2017

DrySyn Evaluation:

“I like the DrySyn Scholar, because they negate the need for oil baths, thereby reducing mess and increasing the ease of use for students.

They are well made (survived many a student drop) and robust, whilst there versatility is demonstrated by fitting on many different Hotplate Stirrers. Also the bases allowing different sizes of inserts.

For these reasons, I’m looking to buy more DrySyn Scholars as a safe and effective tool to enhance our teaching laboratory.”

Mrs Laura Spawls, Teaching Co-ordinator, University of East Anglia

 

 

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Smart Evaporator C10 Evaluation: Ryoko Tanaka, Institute of Analytical Sciences, University of Fukuoka (Japan)

Posted on: February 1, 2017

Assistant prof. Ms.Tanaka needed to raise the concentration when detecting amino acids as a target by LC-MS / MS, and had desired the most to avoid the denaturation of samples during concentration in order to evaluate the sample variation over a time. Up to now, she needed to repeat the process with 1-2 samples for some times when she actually needs to evaporate 4 to 6. She was feeling reluctant to do evaporation because it took her so long. Continue reading

Smart Evaporator C10 Evaluation: Anon, Manufacturer

Posted on: December 22, 2016

Smart Evaporator C10 Evaluation:  shared by BioChromato

“BioChromato We’d like to know about your research development with the C10. Thank you very much for this opportunity.
Mr.S My pleasure.
BioChromato What types of research area are you working on?
Mr.S We work in the research of composite material of asphalt and solvents to develop our self-manufactured product.
BioChromato How do you use the C10?
Mr.S To commercialize the composite material developed in our research, we need to exclude the solvents in the last process. We started to use the C10 to significantly improve the work efficiency in the lab.
BioChromato What is the container size and the sample volume you use with the C10?
Mr.S We concentrate 50cc of the sample heated at 60 Celsius in the 100mL screw bottle. The C10 is able to handle the maximum 10 samples at once, and that runs for 2 hours for one operation. We have that process 5 times in a week.
BioChromato Is there any particular benefits you feel with using the C10?
Mr.S The C10 supports the 10 concentrations at once, and this contributes to our work efficiency. It is necessary to increase the number of transactions for commercializing the product, and we need to verify the small amount samples like 50cc for many times so the C10 performs the best with our case. Actually we’ve just also purchased two rotary evaporators, but I asked for the demonstration when the distributor showed us your brochure. The evaporation principal was just something I have never seen.
BioChromato What was the impression you had in the demonstration?
Mr.S It was more than I expected, and I straight away made my mind to purchase. With the rotary evaporator, we used to take 3 to 4 days to concentrate the 10 samples with one flask. Now this takes us only 2 hours without bumping risk. I appreciate for the safe and improved operation.
BioChromato So the demonstration convinced you that this is actually a good apparatus! So after you actually start using this, do you have any new impressions?
Mr.S Once our research material becomes commercialized, that will be manufactured at some tons after 2-3 years. In that case we would need to have the factory scaled evaporation machine with the vacuum-vortex principal. We’d like you to consider the scale-up development in the future.
BioChromato I see. We may have the same request from the other manufacturers in the future. Thank you for your opinion, and we appreciate for your cooperation.”

Mr. S. used to use the rotary evaporator to concentrate the 10 samples for his material development, and that took him 3 to 4 days. The C10 which supports the multiple evaporations handles the 10 evaporations in about 2 hours. Even those who are not experienced with the rotary evaporator can operate the apparatus at ease without bumping risk, and this contributes to the commercialization of their research materials.
(Interviewer: Tsuyoshi Kikuchi)

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Smart Evaporator C10 Evaluation: Anon. C10 reduces capacity issues

Posted on: November 30, 2016

Smart Evaporator C10 Evaluation: Anon. Shared by BioChromato

“No more scrambles for the Smart Evaporator C1,
but now we have the C10!

The Smart Evaporator C10 is now newly introduced to the laboratory of Dr.K.
(interviewed with Dr. “K” in the university “T” in natural product chemistry research)

BioChromato Thank you very much for purchasing the C10.The last time we had a great contribution from you for the testimonial of C1, but again we would be appreciated to know your impression of using the multi-positioned Smart Evaporator.

Dr.K I would also be pleased to do so.

BioChromato I heard that the Smart Evaporator’s been widely used among students, and there was a queue to wait for turn.

Dr.K Yes, the students were waiting for their turn to use the C1.

BioChromato Why did the students prefer to use the C1?

Dr.K I can say that’s because the evaporator is free from bumping. We can hardly collect the fluorescent substance samples once they bump, and also it was too much burden to clean for many times so we had an issue on how to avoid samples to be bumped.

BioChromato I see. So the one single C1 was not enough for the demands of all the students. Then now you’ve selected the multi-positioned C10.

Dr.K That’s right. When I first saw that at one of the conference, I already made my mind. Once I had the budget ready, I decided to purchase that without hesitation.

BioChromato I’m honoured to have your interests from the time you first saw it at the conference. So how is that working at your lab and do you come up with new impressions?
C10 just installed at her lab.

Dr.K When setting up the vials and the Spiral Plugs, it’s very smooth to lift up and down the heating block so I found it’s far easier than the C1. And also the valves are well designed that use the motif of flower or leaf. I think it’s great you are particular about the details too.

BioChromato We appreciate to have your compliments and will be pleased to have further feedbacks again. Thank you very much for your time today.”

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The University of Nottingham and their use of the Smart Evaporator

Posted on: November 30, 2016

Interview with Dr Tom McInally at The University of Nottingham as to the benefits of the BioChromato Smart Evaporator

Q What type of laboratory are you in charge of?

A We have been using the Smart Evaporator particularly well in our Medicinal Chemistry teaching module in an undergraduate teaching laboratory where we synthesise and we send samples to our partner laboratory (Industrial Pharma company) for biological screening.

Q Why try the Smart Evaporator?

A To prepare a 3-5mg sample for biological screening in the vials of choice of our partner and 1 mg sample for LCMS analysis

Q How many types of vial are used in conjunction with your smart evaporator?

A Let me show you: From left to right (shown with smart evaporator Spiral Plugs) Larger volume storage vial, Test vial for partner screening system, Recovery vial for NMR samples, usually in DMSO works very well, LCMS vial sent to partner for QC.

spiral-plugs-nottingham

Q What are you generally evaporating?

A Final compounds after purification by Flash Chromatography, HPLC, SPE and after Crystallizations too. We find that by dissolving a known amount of compound we can then evaporate to dryness making it easy to get precise amounts of material per vial.

Q What did you use before the Smart evaporator?

A Before we had to use a standard Rotary Evaporator, it was not easy to do. We made a special adapter to fit the vials onto the Rotary Evaporator but contamination and bumping was a serious issue. The Smart Evaporator almost totally eliminates these issues. These small samples also tied up the Rotary Evaporator for long periods of time when it was more often needed (and suitable for) for large volume flask evaporation. We also found removing DMSO almost impossible with the Rotary Evaporator where as in the Smart Evaporator it works well.

Q Have you tried round Bottom Flask evaporation?

A Yes in small flasks of 25ml round bottom flasks it works well, especially taking water/methanol samples to dryness after SPE

Q Other post synthesis benefits?

A Allows ease to swap solvents so for instance removing Acetonitrile andDMF for ease of work up

Q What scales are you generally working on?

A 2-50mg per ml

Q How easy has it been to use the Smart evaporator?

A Undergraduate students have found it very easy to use unsupervised, they have also been very keen to continue using the Smart evaporator as its proven much easier to use than the Rotary Evaporators.

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Smart Evaporator C10 Evaluation: Anon, Analysis Div Chemical Manufacturer

Posted on: November 30, 2016

Smart Evaporator C10 Evaluation:  shared by BioChromato

“We are now able to concentrate multiple samples of water and mixed solvents, which had been necessary as a pre-processing step in component analysis, with just this one single instrument!” Mr O, member of the analysis team in the pharmaceutical products division of a chemical manufacturer says 

“In the past, we had to use numerous instruments to do our work—freeze-dryers, centrifugal evaporators, nitrogen blowers, and rotary evaporators—and we had to use different instruments for different samples. . . The great thing about the Smart Evaporator is that we can do everything at the pre-processing stage with just this one machine, no matter how much or which types of solvent we want to evaporate! This has allowed us to reduce the time required for a single operation by over 4 hours.”

“For liquid-liquid extraction, we sometimes use solvents like chloroform or hexane, and it’s surprising how few instruments out there can handle these substances. That makes the C10 all the more valuable.”

“The fact that the vacuum pump requires no oil changes, and that we can perform concentration as is, even with organic solvents, is a particularly attractive feature of the C10.”

“After we actually installed the C10, we were able to handle many different samples with just this single instrument, which increased our productivity as we were expecting. In the past, when using a freeze-dryer for solvents such as water, we had to keep an eye on things for an hour or so after starting, to make sure there was no bumping. Then, we would let the evaporation process take place overnight, but in some cases it still wasn’t finished the following morning.”

(Vessels used: 50-ml screw-cap vial; 10-ml screw-cap test tube. Solvents used: water; mixed solvents such as water mixed with acetonitrile or methanol. Sample volume: from less than 1 ml to as much as 150 ml or so.)

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