Publication 38: Continuous Flow alpha-Trifluoromethylation of Ketones under Metal-Free Visible Light Photoredox Catalysis

Flow Chemistry Publication 38





NEW Flow Chemistry Publication: A continuous-flow, two-step procedure for the preparation of a-CF3-substituted carbonyl compounds has been developed using the Uniqsis Binary Pump Module in combination with a lab built photoreactor.

The carbonyl substrates were converted in situ into the corresponding silyl enol ethers, mixed with the CF3 radical source, and then irradiated with visible light using a flow reactor based on transparent tubing and a household compact fluorescent lamp.

The continuous protocol uses Eosin Y as an inexpensive photoredox catalyst and requires only 20 min to complete the two reaction steps.

See the Uniqsis FlowSyn system and read more of our Flow Chemistry publications and application notes.