Pre-cooling loops are incorporated for all 3 reactor input streams and gaseous reagent inputs can be easily introduced by attaching a ‘tube-in’tube’ presaturation module.
The full paper is available HERE
J. A. Newby, D. W. Blaylock, P. M. Witt, J. C. Pastre, M. K. Zacharova, S. V. Ley, D. L. Browne, Org. Process Res. Dev., 2015, 4OI: 10.1021/op500213j